RESUMO
PET imaging with 68Ga-labeled tracers has seen a dramatic increase over the past five years primarily due to the increased accessibility of 68Ge/68Ga generators, the availability of tracers with superb targeting properties for labeling, straightforward labeling procedures and the approval of these tracers by regulatory entities. Available 68Ge/68Ga generators nominally deliver up to 1.85 GBq (50mCi) when fresh limiting production and distribution of 68Ga-labeled tracers to a few daily doses per generator. The focus of this study was to provide a simple and efficient method for 68Ga production in clinically relevant quantities using a low energy medical cyclotron with a solid target.
Assuntos
Radioisótopos de Gálio/isolamento & purificação , Ciclotrons , Radioisótopos de Gálio/química , Germânio/química , Germânio/efeitos da radiação , Humanos , Espectrometria de Massas , Tomografia por Emissão de Pósitrons , Radioisótopos/química , Compostos Radiofarmacêuticos/química , Compostos Radiofarmacêuticos/isolamento & purificação , Tecnologia Radiológica , Isótopos de Zinco/química , Isótopos de Zinco/efeitos da radiaçãoRESUMO
Interest in using (89)Zr is rapidly increasing for immuno-PET applications due to its unique characteristics and increased availability. The focus of this study was to develop an optimized semi-automated methodology for producing (89)Zr-oxalate/(89)Zr-chloride, and evaluate the potential application of (89)Zr-chloride for radiopharmaceutical compounding. The data presented herein will be useful for the production of (89)Zr-labeled radiopharmaceuticals and their compliance with regulatory issues for both preclinical and clinical use.
